To answer my own question, I personally would have a great problem with practicing in space for any length of time. My HP reminded me that the sacred space in circle is not "on Earth" anyway so, duh, why would I have a problem, but I am a little more elemental than that.
My understanding of the elements, and how they play a part in the craft, is based on elements as part of the Earth. so air is not canned oxygen, but the wind; Water is the surging ocean, or riushing river, not that in the recirculating system. And while I can visualize the elements from memory, how would my off spring or their off spring do so, if all they knew was off world?
Huh.. Interesting

My first reaction was.. no, I couldn't, I've become really attuned to the earth and her cycles (I'd've been ok in my pre-pagan days i think). However, your comment on circle gave me the answer. I view a sacred circle as representing all that is, granted at this point I'm not using it often. And the elements aren't something we can get away from (think the 3 states of matter, 4 with plasma - wouldn't be the same, but the next generations would get the idea

). I guess I'd prolly become more wiccan in my rituals, though.
On cycles, there are so many, the life/death/birth mysteries wouldn't go anywhere. Nor would women's mysteries. I'm sure there are a lot more I'm forgetting. For me, the most important aspect is that I don't think Hecate would have any problem with space! And I view divinity as all pervading, so I wouldn't be getting away from the divine. Though I would have one heck of a shrine to Gaia!! Or the Earth in some other aspect